Which is a contraindication for MHT?

Which is a contraindication for MHT?

• A. History of breast or endometrial cancer, stroke, myocardial infarction, blood clots, and liver disease
• B. History of osteoporosis only
• C. Regular exercise
• D. Normal liver function

Answer: (A)

When evaluating menopausal hormone therapy, safety hinges on conditions that raise the risks of hormone-related complications. The strongest contraindication is a history of cancers that can be hormone-sensitive (such as breast or endometrial cancer), plus major cardiovascular events or clotting problems (stroke, myocardial infarction, blood clots), and significant liver disease. Estrogen therapy can fuel the growth of hormone-sensitive tumors, increase the risk of clot formation, and worsen liver conditions, so having any of these histories means MHT should generally be avoided. The other options don’t fit as contraindications. A history of osteoporosis alone is not a contraindication; MHT can be used to help bone density in some patients. Regular exercise is not a barrier to MHT, and normal liver function indicates there isn’t a liver-related reason to avoid therapy.

When evaluating menopausal hormone therapy, safety hinges on conditions that raise the risks of hormone-related complications. The strongest contraindication is a history of cancers that can be hormone-sensitive (such as breast or endometrial cancer), plus major cardiovascular events or clotting problems (stroke, myocardial infarction, blood clots), and significant liver disease. Estrogen therapy can fuel the growth of hormone-sensitive tumors, increase the risk of clot formation, and worsen liver conditions, so having any of these histories means MHT should generally be avoided.

The other options don’t fit as contraindications. A history of osteoporosis alone is not a contraindication; MHT can be used to help bone density in some patients. Regular exercise is not a barrier to MHT, and normal liver function indicates there isn’t a liver-related reason to avoid therapy.